ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate

Base Information

• Chemical Name: ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate
• CAS No.: 125040-80-4
• Molecular Formula: C₁₆H₁₅N₃O₃
• Molecular Weight: 297.313
• Mol file: 125040-80-4.mol

Synonyms:ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate

Chemical Property of ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate

There total 5 articles about ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl (2E)-3-oxo-2-(2-(4-methylphenyl)hydrazinylidene)butanoate (18804-77-8) + ethyl 2-cyanoacetate (105-56-6) → ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate (125040-80-4)

Guidance literature:

With ammonium acetate; In acetic acid; at 75 ℃; for 0.0138889h; irradiation in microwave oven;

DOI:10.1080/00397919708004105

Reference yield: 82.0%

ethyl (Z)-3-oxo-2-(2-p-tolylhydrazinylidene)butanoate (18804-77-8) + ethyl 2-cyanoacetate (105-56-6) → ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate (125040-80-4)

Guidance literature:

With ammonium acetate; In acetic acid; benzene; at 160 ℃; for 7h;

Reference yield: 66.9%

ethyl 2-cyanoacetate (105-56-6) + ethyl 3-oxo-2-(p-tolylhydrazono)butanoate (18804-77-8) → ethyl-5-cyano-1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)-3-pyridazinecarboxylate (125040-80-4)

Guidance literature:

With ammonium acetate; at 140 ℃; for 0.5h;

upstream raw materials:

1-cyano-1,3-diethoxycarbonyl-2-methyl-1-propene

p-methylbenzenediazonium chloride

ethyl (Z)-3-oxo-2-(2-p-tolylhydrazinylidene)butanoate

ethyl 2-cyanoacetate

Downstream raw materials:

5-Cyano-6-oxo-4-(2-piperidin-1-yl-ethyl)-1-p-tolyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester

5-Cyano-4-((E)-2-furan-2-yl-vinyl)-6-oxo-1-p-tolyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester

5-Amino-6-cyano-7-(4-methoxy-phenyl)-4-oxo-3-p-tolyl-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester

5-Amino-6-cyano-7-furan-2-yl-4-oxo-3-p-tolyl-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester