2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

Base Information

Chemical Name:2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester
CAS No.:1333398-78-9
Molecular Formula:C₂₆H₂₇N₃O₃
Molecular Weight:429.519
Hs Code.:

Synonyms:2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

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Chemical Property of 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

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Technology Process of 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

There total 11 articles about 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₅N₃O₅

: 1333398-78-9
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

Guidance literature:: In dichloromethane; at 30 ℃; for 16h; Acidic conditions;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 1333400-87-5
[2-bromo-4-(pyridin-4-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester

: 1333398-78-9
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

2.1: trialkylamine

2.2: 20 °C

3.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 1333400-90-0
2'-(tert-butoxycarbonylamino-methyl)-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid

: 1333398-78-9
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trialkylamine

1.2: 20 °C

2.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With trialkylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2013.09.040