5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Base Information

• Chemical Name: 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate
• CAS No.: 1205539-48-5
• Molecular Formula: C₁₆H₁₄N₆O₄S
• Molecular Weight: 386.391

Synonyms:5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Chemical Property of 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Chemical Property:

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Technology Process of 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

There total 2 articles about 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(tert-butyldimethylsilyloxy)-5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)phenyl sulfamate (1205539-46-3) → 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate (1205539-48-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.steroids.2009.06.006

Reference yield: 17.0%

2-benzyloxy-5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)phenyl sulfamate (1205539-42-9) → 5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate (1205539-48-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃;

DOI:10.1016/j.steroids.2009.06.006

Reference yield:

5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate (1205539-48-5) + [11C]methyl triflate (145577-00-0) → 5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-[11C]methoxyphenyl sulfamate (1205539-50-9)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 80 ℃; for 0.05h;

DOI:10.1016/j.steroids.2009.06.006

upstream raw materials:

2-benzyloxy-5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)phenyl sulfamate

2-(tert-butyldimethylsilyloxy)-5-(((4-cyanophenyl)(4H-1,2,4-triazole-4-yl)amino)methyl)phenyl sulfamate

Downstream raw materials:

5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-[¹¹C]methoxyphenyl sulfamate

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