(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

Base Information

Chemical Name:(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol
CAS No.:104303-09-5
Molecular Formula:C₂₀H₂₄O₄S
Molecular Weight:360.474
Hs Code.:

Synonyms:(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

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Chemical Property of (R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

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Technology Process of (R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

There total 11 articles about (R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 104303-07-3
(2R,3'S)-5,8-Dimethoxy-1,2,3,4-tetrahydronaphthalene-2-spiro-3'-hydroxymethyl-2'-oxirane

: 108-98-5
thiophenol

: 104303-08-4
(R)-2-<1(S)-Hydroxy-2-phenylthioethyl>-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol

: 104303-09-5
(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: With sodium hydroxide; In various solvent(s); at 85 - 90 ℃;
DOI:10.1016/S0040-4039(00)99036-1

Reference yield:

: 104303-02-8
2-Allyl-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

: 104303-09-5
(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine, / 4-dimethylaminopyridine / CH₂Cl₂

2: triethylamine / 4-dimethylaminopyridine / toluene / 40 h / 80 °C

3: 91 percent / H₂ / naphthalene*Cr(CO)3 / acetone / 13 h / 45 °C / 102971 Torr

4: potassium carbonate / methanol

5: 97 percent / (+)-diethyl tartrate, titanium-(IV) isopropoxide, t-butylhydroperoxide, molecular sieves / 2.5 h / -40 °C

6: 17 percent / 0.5 N NaOH / various solvent(s) / 85 - 90 °C

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium hydroxide; molecular sieve; hydrogen; potassium carbonate; (+)-Weinsaeure-diethylester; triethylamine; dmap; naphthalene; chromium tricarbonyl; In methanol; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)99036-1

Reference yield:

: 104303-04-0
(2-Hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-acetaldehyde

: 104303-09-5
(R)-2-((R)-2-Hydroxy-1-phenylsulfanyl-ethyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 4-dimethylaminopyridine / toluene / 0.67 h / 80 °C

2: 91 percent / H₂ / naphthalene*Cr(CO)3 / acetone / 13 h / 45 °C / 102971 Torr

3: potassium carbonate / methanol

4: 97 percent / (+)-diethyl tartrate, titanium-(IV) isopropoxide, t-butylhydroperoxide, molecular sieves / 2.5 h / -40 °C

5: 17 percent / 0.5 N NaOH / various solvent(s) / 85 - 90 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium hydroxide; molecular sieve; hydrogen; potassium carbonate; (+)-Weinsaeure-diethylester; triethylamine; dmap; naphthalene; chromium tricarbonyl; In methanol; acetone; toluene;
DOI:10.1016/S0040-4039(00)99036-1