diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate

Base Information

• Chemical Name: diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate
• CAS No.: 1379148-12-5
• Molecular Formula: C₂₃H₂₀NO₆P
• Molecular Weight: 437.389
• Mol file: 1379148-12-5.mol

Synonyms:diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate

Chemical Property of diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate

There total 4 articles about diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N,N-(1,8-naphthaloyl)-2-aminobenzoyl chloride (56813-57-1) + triethyl phosphite (122-52-1) → diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate (1379148-12-5)

Guidance literature:

In toluene; at 70 ℃; for 0.5h;

DOI:10.1039/c2ob25314c

Reference yield:

2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzoic acid (56813-55-9) → diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate (1379148-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C

2: toluene / 0.5 h / 70 °C

With thionyl chloride; N,N-dimethyl-formamide; In toluene;

DOI:10.1039/c2ob25314c

Reference yield:

1,8-Naphthalic anhydride (81-84-5) → diethyl {2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)}benzoylphosphonate (1379148-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 16 h / 140 °C

2: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C

3: toluene / 0.5 h / 70 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; toluene;

DOI:10.1039/c2ob25314c

upstream raw materials:

1,8-Naphthalic anhydride

anthranilic acid

N,N-(1,8-naphthaloyl)-2-aminobenzoyl chloride

triethyl phosphite

Downstream raw materials:

triethyl phosphate

diethyl (7,13-dioxo-13,13a-dihydro-7H-benzo[de]indolo[2,1-a]isoquinolin-13a-yl)phosphonate

diethyl 7-oxo-7H-benzo[de]indolo[2,1-a]isoquinolin-13-ylphosphate

C₂₇H₃₁NO₉P₂