1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• CAS No.: 549072-24-4
• Molecular Formula: C₁₃H₁₂F₃N₃O₂
• Molecular Weight: 299.252

Synonyms:1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property of 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

There total 4 articles about 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl azide (622-79-7) + (Z) ethyl 3-trifluoromethyl-3-pyrrolidino-acrylate (363617-87-2) → 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (549072-24-4)

Guidance literature:

With sodium carbonate; at 95 ℃; for 72h;

DOI:10.1055/s-2003-36784 DOI:10.1016/S0040-4020(03)00621-5

Reference yield: 76.0%

3-benzylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester (150892-04-9) → 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (549072-24-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; In acetonitrile; at -20 - 20 ℃; for 24h;

DOI:10.1002/ejoc.201300030

Reference yield: 60.0%

2-carboethoxy-3-trifluoromethyl-7-oxabicyclo<2.2.1>hepta-2,5-diene (137348-36-8) + benzyl azide (622-79-7) → 3-benzyl-5-trifluoromethyl-3H-[1,2,3]triazole-4-carboxylic acid ethyl ester (851884-09-8) + 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (549072-24-4)

Guidance literature:

In d⁽⁴⁾-methanol; at 20 ℃; for 16h; Product distribution / selectivity;

upstream raw materials:

benzyl azide

(Z) ethyl 3-trifluoromethyl-3-pyrrolidino-acrylate

2-carboethoxy-3-trifluoromethyl-7-oxabicyclo<2.2.1>hepta-2,5-diene

3-benzylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester

Downstream raw materials:

1-benzyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic acid

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