1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Base Information

Chemical Name:1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine
CAS No.:140134-85-6
Molecular Formula:C₃₃H₃₆N₂O₇
Molecular Weight:572.658
Hs Code.:

Synonyms:1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Suppliers and Price of 1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

There total 8 articles about 1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 140134-84-5
C₃₅H₄₀N₂O₆Si

: 140134-85-6
1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Guidance literature:: With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; Ambient temperature; 1) benzene, 2) THF, methanol, RT, overnight;
DOI:10.1016/S0040-4020(01)88147-3

Reference yield:

: 140134-83-4
1-<5'-O-(monomethoxytrityl)-(3'-O-allyldimethylsilyl)-2'-deoxy-2'-phenylseleno-β-D-xylofuranosyl>thymine

: 140134-85-6
1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Guidance literature:: With potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; potassium hydrogencarbonate; Yield given. Multistep reaction; 1) benzene, 2) THF, methanol, RT, overnight;
DOI:10.1016/S0040-4020(01)88147-3

Reference yield:

: 134934-45-5
1-(5'-O-(monomethoxytrityl)-2',3'-O-anhydro-β-D-lyxofuranosyl)thymine

: 140134-85-6
1-<5'-O-(monomethoxytrityl)-2'-deoxy-2'-C(S)-((2-(S)-hydroxymethyl)ethylene)-β-D-lyxofuranosyl>-5(R),6(S)-dihydrothymine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LiAlH₄ / 1) THF, reflux, 10 min, 2) reflux, 2 h

2: 100 percent / pyridine / 2 h / Ambient temperature

3: 1) tri-n-butyltin hydride , AIBN, 2) KF, KHCO₃, aq. H₂O₂ / 1) benzene, 2) THF, methanol, RT, overnight

With pyridine; potassium fluoride; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; potassium hydrogencarbonate;
DOI:10.1016/S0040-4020(01)88147-3