[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

Base Information

Chemical Name:[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine
CAS No.:1072930-80-3
Molecular Formula:C₂₂H₂₀ClFN₄
Molecular Weight:394.879
Hs Code.:

Synonyms:[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

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Chemical Property of [2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

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Technology Process of [2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

There total 8 articles about [2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1072928-93-8
5-fluoro-N₁-propylbenzene-1,2-diamine

: 1072930-81-4
3-chloro-4-(6-methyl-pyridin-3-ylamino)-benzoyl chloride

: 1072930-80-3
[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

Guidance literature:: 5-fluoro-N₁-propylbenzene-1,2-diamine; 3-chloro-4-(6-methyl-pyridin-3-ylamino)-benzoyl chloride; In tetrahydrofuran; at 60 ℃; for 15h;

With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 24h;

Reference yield:

: C₂₂H₂₂ClFN₄O

: 1072930-80-3
[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 24h;

Reference yield:

: 80287-53-2,3430-14-6
5-Amino-2-methylpyridine

: 1072930-80-3
[2-chloro-4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-(6-methyl-pyridin-3-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 80 °C

2.1: methanol; sodium hydroxide; water / 2 h / 70 °C

2.2: pH 6 - 7

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 1 h / 20 - 80 °C

4.1: tetrahydrofuran / 15 h / 60 °C

4.2: 24 h / 110 °C

With methanol; sodium hydroxide; thionyl chloride; water; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;