N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

Base Information

Chemical Name:N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide
CAS No.:211745-53-8
Molecular Formula:C₆₇H₉₁N₉O₂₂
Molecular Weight:1374.51
Hs Code.:

N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

Synonyms:N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

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Chemical Property of N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

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Technology Process of N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

There total 6 articles about N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 56074-20-5
N-((tert-butyloxy)carbonyl)iminodiacetic acid

: (S)-2-Benzyloxycarbonylamino-6-(2-{[(3,4,5-trimethoxy-benzylcarbamoyl)-methyl]-amino}-acetylamino)-hexanoic acid methyl ester; hydrochloride

: 211745-53-8
N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1016/S0040-4020(98)00128-8

Reference yield:

: 56074-20-5
N-((tert-butyloxy)carbonyl)iminodiacetic acid

: (S)-2-Benzyloxycarbonylamino-6-(2-{[(3,4,5-trimethoxy-benzylcarbamoyl)-methyl]-amino}-acetylamino)-hexanoic acid methyl ester

: 211745-53-8
N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1016/S0960-894X(98)00423-5

Reference yield:

: 206867-09-6
N-((tert-butyloxy)carbonyl)-N'-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)iminodiacetic acid monoamide

: 211745-53-8
N,N'-bis(N-(3,4,5-trimethoxybenzyl)carboxamidomethyl)-N,N'-bis(N-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; iPr₂NEt / dimethylformamide / 16 h / 25 °C

2: 4 M HCl / dioxane / 4 h / 25 °C

3: PyBrOP; iPr₂NEt / dimethylformamide / 16 h / 25 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00423-5