N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide

Base Information

• Chemical Name: N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide
• CAS No.: 852042-12-7
• Molecular Formula: C₁₇H₁₅F₃N₂O₂S
• Molecular Weight: 368.38
• Mol file: 852042-12-7.mol

Synonyms:N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property of N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide

There total 3 articles about N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.6%

trifluoromethylsulfonic anhydride (358-23-6) + 1-(3,5-dimethylphenyl)-5-aminoindole (360045-07-4) → N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide (852042-12-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2005.03.002

Reference yield:

1-(3,5-dimethyl-phenyl)-5-nitro-1H-indole (852042-10-5) → N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide (852042-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.9 percent / hydrogen / Pd/C / ethyl acetate / 3 h / 20 °C

2: 31.6 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.03.002

Reference yield:

3,5-dimethylphenyl boronic acid (172975-69-8) → N-[1-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-C,C,C-trifluoro-methanesulfonamide (852042-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Cu(CH₃COO)2; triethylamine; molecular sieves 3 Angstroem / CH₂Cl₂

2: 81.9 percent / hydrogen / Pd/C / ethyl acetate / 3 h / 20 °C

3: 31.6 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With 3 A molecular sieve; hydrogen; copper diacetate; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.03.002

upstream raw materials:

trifluoromethylsulfonic anhydride

1-(3,5-dimethylphenyl)-5-aminoindole

1-(3,5-dimethyl-phenyl)-5-nitro-1H-indole

3,5-dimethylphenyl boronic acid