(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

Base Information

Chemical Name:(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol
CAS No.:1609170-58-2
Molecular Formula:C₃₀H₃₇N₇O₄S
Molecular Weight:591.734
Hs Code.:

(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

Synonyms:(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

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Chemical Property of (7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

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Technology Process of (7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

There total 12 articles about (7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609171-12-1
N-(2-(isopropylsulfonyl)phenyl)-3-methyl-6-(methylsulfonyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1609171-34-7
(7-amino-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

: 1609170-58-2
(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; at 160 ℃; for 5h; Sealed tube;

Reference yield:

: 1-(allyloxy)-4-methyl-2-nitrobenzene

: 1609170-58-2
(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 5 h / 200 °C

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 85 °C

3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 12 h / 20 °C

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

5: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 1 h / 135 °C / Inert atmosphere

6: triethylamine; hydrogen; platinum(IV) oxide; acetic acid / 24 h / 20 °C / 4551.02 Torr

7: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With platinum(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1609171-31-4
(7-amino-5-methyl-2,3-dihydrobenzofuran-2-yl)methanol

: 1609170-58-2
(7-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-5-methyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 1 h / 135 °C / Inert atmosphere

3: triethylamine; hydrogen; platinum(IV) oxide; acetic acid / 24 h / 20 °C / 4551.02 Torr

4: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 160 °C / Sealed tube

With platinum(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol;