ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate

Base Information

• Chemical Name: ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate
• CAS No.: 1246285-35-7
• Molecular Formula: C₂₀H₃₄O₃Si
• Molecular Weight: 350.574
• Mol file: 1246285-35-7.mol

Synonyms:ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate

Chemical Property of ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate

There total 1 articles about ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

t-butyldimethylsiyl triflate (69739-34-0) + (±)-ethyl 2-oxo-1-(pent-4-yn-1-yl)cyclohexane-1-carboxylate (42797-82-0) → ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate (1246285-35-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol101860j

Reference yield:

ethyl 2-(tert-butyldimethylsiloxy)-1-(4-pentyn-1-yl)-2-cyclohexenecarboxylate (1246285-35-7) → ethyl cis-5-methylene-10-oxobicyclo[4.3.1]decane-1-carboxylate + (±)-ethyl 2-oxo-1-(pent-4-yn-1-yl)cyclohexane-1-carboxylate (42797-82-0)

Guidance literature:

With [Au(NTf)₂(Si-dtbm)]; tert-butyl alcohol; In dichloromethane; at 25 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/ol101860j

upstream raw materials:

t-butyldimethylsiyl triflate

(±)-ethyl 2-oxo-1-(pent-4-yn-1-yl)cyclohexane-1-carboxylate

Downstream raw materials:

(±)-ethyl 2-oxo-1-(pent-4-yn-1-yl)cyclohexane-1-carboxylate