1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Base Information

Chemical Name:1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole
CAS No.:1567334-74-0
Molecular Formula:C₂₈H₃₅ClN₂O₂
Molecular Weight:467.051
Hs Code.:

Synonyms:1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Chemical Property of 1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

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Technology Process of 1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

There total 9 articles about 1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1567335-35-6
2-(5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl)phenol

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1567334-74-0
1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: In toluene; at 80 ℃;

Reference yield:

: 1567335-31-2
benzotriazol-1-yl-(2,2,6,6-tetramethyltetrahydropyran-4-yl)methanone

: 1567334-74-0
1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: magnesium bromide diethyl etherate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: ethanol / 4 h / 80 °C

3: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / 80 °C

5: boron tribromide / dichloromethane / 1 h / -78 °C

6: toluene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; magnesium bromide diethyl etherate; boron tribromide; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1197-66-6
2,2,6,6-tetramethyltetrahydropyran-4-one

: 1567334-74-0
1-(2-tert-butoxyphenyl)-5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1: potassium tert-butylate / tert-butyl alcohol; 1,2-dimethoxyethane / 0 - 35 °C / Reflux

2: thionyl chloride / dichloromethane / 8 h / 20 °C

3: magnesium bromide diethyl etherate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: ethanol / 4 h / 80 °C

5: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 6 h / 80 °C

7: boron tribromide / dichloromethane / 1 h / -78 °C

8: toluene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; magnesium bromide diethyl etherate; potassium tert-butylate; boron tribromide; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene; tert-butyl alcohol;