(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

Base Information

Chemical Name:(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one
CAS No.:1071519-50-0
Molecular Formula:C₂₃H₂₁FN₄O₄S
Molecular Weight:468.509
Hs Code.:

Synonyms:(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

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Chemical Property of (1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

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Technology Process of (1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

There total 14 articles about (1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071520-41-6
(1S,2R,3S,4R)-3-(4-fluoro-benzylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

: 1071522-83-2
sodium (1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)acetate

: 1071519-50-0
(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

Guidance literature:: (1S,2R,3S,4R)-3-(4-fluoro-benzylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester; sodium (1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)acetate; With HATU; In N,N-dimethyl-formamide; at 25 ℃; for 1.5h;

With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 498-66-8
norborn-2-ene

: 1071519-50-0
(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl acetate / 0 - 25 °C / Industry scale

1.2: 0 - 25 °C / Industry scale

1.3: 0 - 15 °C / pH 7 / Industry scale

2.1: ethyl acetate / 50 - 75 °C / Industry scale

3.1: sodium hydrogencarbonate / ethyl acetate; water / 0.5 h / 25 °C

4.1: sodium cyanoborohydride; acetic acid / ethanol / 3 h / 25 °C

4.2: 0.5 h

5.1: HATU / N,N-dimethyl-formamide / 1.5 h / 25 °C

5.2: 16 h / 50 °C

With sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; HATU; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 7486-95-5,14805-23-3
exo-3-azatricyclo<4.2.1.0^2,5>nonan-4-one

: 1071519-50-0
(1R,2S,7R,8S)-5-(1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triazanaphthalen-3-yl)-3-(4-fluorobenzyl)-6-hydroxy-3-azatricyclo[6.2.1.02,7]undec-5-en-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl acetate / 50 - 75 °C / Industry scale

2.1: sodium hydrogencarbonate / ethyl acetate; water / 0.5 h / 25 °C

3.1: sodium cyanoborohydride; acetic acid / ethanol / 3 h / 25 °C

3.2: 0.5 h

4.1: HATU / N,N-dimethyl-formamide / 1.5 h / 25 °C

4.2: 16 h / 50 °C

With sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; HATU; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;