4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

Base Information

Chemical Name:4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol
CAS No.:940953-30-0
Molecular Formula:C₂₈H₃₀N₂O₃S₃
Molecular Weight:538.756
Hs Code.:

Synonyms:4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

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Chemical Property of 4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

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Technology Process of 4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

There total 7 articles about 4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{5-[((E)-(1R,2R)-2-{[1-(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-yl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-thiophen-2-yl}-phenol

: 940953-30-0
4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h;
DOI:10.1002/adsc.200606125

Reference yield:

: 4701-17-1
5-bromo-2-thiophencarboxaldehyde

: 940953-30-0
4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. Na₂CO₃ / PdCl₂(PPh₃)2 / 1,2-dimethoxy-ethane; ethanol / Heating

2: Et₃N; MgSO₄ / CH₂Cl₂ / 32 h / 20 °C

3: 150 mg / NaBH₄ / methanol / 16 h / 20 °C

With sodium tetrahydroborate; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 1: Suzuki cross-coupling;
DOI:10.1002/adsc.200606125

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 940953-30-0
4-[5-({(1R,2R)-2-[(7-Thiophen-2-yl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-ylmethyl)-amino]-cyclohexylamino}-methyl)-thiophen-2-yl]-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. Na₂CO₃ / PdCl₂(PPh₃)2 / 1,2-dimethoxy-ethane; ethanol / Heating

2: Et₃N; MgSO₄ / CH₂Cl₂ / 32 h / 20 °C

3: 150 mg / NaBH₄ / methanol / 16 h / 20 °C

With sodium tetrahydroborate; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 1: Suzuki cross-coupling;
DOI:10.1002/adsc.200606125