N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Chemical Name:N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine
CAS No.:1290126-62-3
Molecular Formula:C₂₇H₃₇N₃O₄S₂
Molecular Weight:531.74
Hs Code.:

N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Synonyms:N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Chemical Property of N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

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Technology Process of N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

There total 6 articles about N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1290128-08-3
C₂₆H₃₅N₃O₅S₂

: 1290126-62-3
N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: C₂₆H₃₅N₃O₅S₂; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: ethyl 7-formyl-6-methyl-2-(methylthio)pyrazolo[5,1-b][1,3]thiazole-3-carboxylate

: 1290126-62-3
N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium permanganate / water; acetone / 0.75 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 1.5 h / 20 °C

3.1: silver carbonate; potassium hydroxide / water / 1.5 h / 20 °C

3.2: 5 h / 75 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 110 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 2.5 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.2: 0.17 h / 20 °C

With potassium permanganate; water; sodium hydride; sodium carbonate; silver carbonate; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1290127-74-0
ethyl 7-[(tert-butoxycarbonyl)amino]-6-methyl-2-(methylthio)pyrazolo[5,1-b][1,3]thiazole-3-carboxylate

: 1290126-62-3
N-(Cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]thiazole-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 1.5 h / 20 °C

2.1: silver carbonate; potassium hydroxide / water / 1.5 h / 20 °C

2.2: 5 h / 75 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 110 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 2.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.2: 0.17 h / 20 °C

With water; sodium hydride; sodium carbonate; silver carbonate; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;