(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

Base Information

Chemical Name:(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol
CAS No.:895532-58-8
Molecular Formula:C₁₇H₂₆O₄
Molecular Weight:294.391
Hs Code.:

Synonyms:(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

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Chemical Property of (1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

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Technology Process of (1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

There total 5 articles about (1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 895532-57-7
(1R,3R,4R)-1-(tert-butyldimethylsilyloxy)-3-benzyloxy-2,2-dimethyl-4-(2-methoxymethoxyethyl)cyclobutane

: 895532-58-8
(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 8h;
DOI:10.1021/ol060827j

Reference yield:

: (4S,5R)-4-benzyloxy-2-methoxy-3,3-dimethyl-5-vinyltetrahydrofuran

: 895532-58-8
(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 67 percent / BF₃*OEt₂; n-butyllithium / Cp₂ZrCl₂ / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / -78 °C

3.1: BH₃*THF / tetrahydrofuran / 4 h / -10 - 20 °C

3.2: 91 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

4.1: 100 percent / ethyldiisopropylamine / CHCl₃ / 48 h / 40 °C

5.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 8 h

With 2,6-dimethylpyridine; n-butyllithium; borane-THF; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; zirconocene dichloride; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/jo070861r

Reference yield:

: 895532-54-4
(1R,3R,4S)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutanol

: 895532-58-8
(1R,3R,4S)-3-benzyloxy-4-[2-(methoxymethoxy)ethyl]-2,2-dimethylcyclobutan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / -78 °C

2.1: BH₃*THF / tetrahydrofuran / 4 h / -10 - 20 °C

2.2: 91 percent / H₂O₂; NaOH / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

3.1: 100 percent / ethyldiisopropylamine / CHCl₃ / 48 h / 40 °C

4.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 8 h

With 2,6-dimethylpyridine; borane-THF; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo070861r