tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane
CAS No.:204448-41-9
Molecular Formula:C₃₈H₅₁IO₇Si
Molecular Weight:774.809
Hs Code.:

tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Synonyms:tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

There total 7 articles about tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 88023-78-3
para-methoxybenzyl chloride

: 204448-69-1
[(2R,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 204448-41-9
tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/(sici)1521-3773(19980202)37:1/2<187::aid-anie187>3.0.co;2-d

Reference yield:

: 204448-66-8
(2R,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-2-((S)-2-methoxy-pent-4-enyl)-tetrahydro-pyran

: 204448-41-9
tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine N-oxide, OsO₄, H₂O / acetone

2: NaIO₄, phosphate buffer (pH 7) / methanol / 0 - 20 °C

3: tert-BuOK / tetrahydrofuran / 1.) -78 deg C, 2.) -78 deg C

4: 1.) Bu₃SnH, AIBN, 2.) NIS, CaCO₃ / 1.) PhMe, 105 deg C, 2.) THF

5: 92 percent / TBAF / tetrahydrofuran

6: 98 percent / (i-Pr)2NEt / CH₂Cl₂

With sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; phosphate buffer; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tetrabutyl ammonium fluoride; water; tri-n-butyl-tin hydride; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1002/(sici)1521-3773(19980202)37:1/2<187::aid-anie187>3.0.co;2-d

Reference yield:

: 204448-40-8
(2R,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-2-((S)-2-methoxy-pent-4-ynyl)-tetrahydro-pyran

: 204448-41-9
tert-Butyl-[(2R,4S,6R)-2-((E)-(S)-5-iodo-2-methoxy-pent-4-enyl)-2-methoxy-6-(4-methoxy-benzyloxymethoxymethyl)-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Bu₃SnH, AIBN, 2.) NIS, CaCO₃ / 1.) PhMe, 105 deg C, 2.) THF

2: 92 percent / TBAF / tetrahydrofuran

3: 98 percent / (i-Pr)2NEt / CH₂Cl₂

With N-iodo-succinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; calcium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/(sici)1521-3773(19980202)37:1/2<187::aid-anie187>3.0.co;2-d