1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

Base Information

Chemical Name:1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate
CAS No.:132875-52-6
Molecular Formula:C₂HF₃O₂*C₁₇H₂₄N₂O₃
Molecular Weight:418.413
Hs Code.:

Synonyms:1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

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Chemical Property of 1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

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Technology Process of 1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

There total 2 articles about 1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 3-[4-(Phenyl-propionyl-amino)-piperidin-1-yl]-propionic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 132875-52-6
1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

Guidance literature:: at 20 ℃; for 1.5h; Time;

Reference yield:

: 1609-66-1
Norfentanyl

: 132875-52-6
1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / acetonitrile / 24 h / 23 °C

2: 88 percent / 1 h / 23 °C

In acetonitrile;
DOI:10.1021/jm00111a041

Reference yield: 92.0%

: 132875-52-6
1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: C₂₄H₃₇N₃O₄

Guidance literature:: 1-piperidine-4-<(1-oxopropyl)phenylamino>propanoic acid trifluoroacetate; tert-butyl 3-aminopropanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 20h;

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h;