N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone

Base Information

• Chemical Name: N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone
• CAS No.: 153779-32-9
• Molecular Formula: C₁₈H₁₉NO₉S
• Molecular Weight: 425.416
• Mol file: 153779-32-9.mol

Synonyms:N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone

Chemical Property of N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone

There total 1 articles about N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-Chloro-2,3-dimethoxybenzoquinone (30839-34-0) + N-mesylanthranilate → N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone (153779-32-9)

Guidance literature:

With 18-crown-6 ether; Celite; cesium fluoride; In N,N-dimethyl-formamide; at 65 ℃; for 5h;

Reference yield:

N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone (153779-32-9) → 2-[Methanesulfonyl-(2,3,4,5-tetramethoxy-phenyl)-amino]-3-methoxy-benzoic acid (153779-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) cetyltrimethylammonium bromide, aq. Na₂S₂O₄, 2.) aq. KOH / 1.) THF, 2.) THF, RT, 14 h

2: 92 percent / 2N aq. KOH / 24 h / Ambient temperature

With potassium hydroxide; sodium dithionite; cetyltrimethylammonim bromide;

Reference yield:

dimethyl sulfate (77-78-1) + N-mesyl-5,6-dimethoxy-2-(6-methoxy-2-methoxycarbonylanilino)-p-benzoquinone (153779-32-9) → N-mesyl-1,4,5,6-tetramethoxy-2-(6-methoxy-2-methoxycarbonylanilino)benzene (153779-47-6)

Guidance literature:

With potassium hydroxide; sodium dithionite; cetyltrimethylammonim bromide; Yield given. Multistep reaction; 1.) THF, 2.) THF, RT, 14 h;

upstream raw materials:

5-Chloro-2,3-dimethoxybenzoquinone

Downstream raw materials:

N-mesyl-1,4,5,6-tetramethoxy-2-(6-methoxy-2-methoxycarbonylanilino)benzene

2-[Methanesulfonyl-(2,3,4,5-tetramethoxy-phenyl)-amino]-3-methoxy-benzoic acid