1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

Base Information

Chemical Name:1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine
CAS No.:148927-84-8
Molecular Formula:C₃₂H₅₂N₄O₇S₂
Molecular Weight:668.919
Hs Code.:

1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

Synonyms:1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

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Chemical Property of 1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

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Technology Process of 1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

There total 3 articles about 1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 148928-09-0
N-Boc-N-methyl-L-methionine sulfone

: 148927-58-6
1-(((7,7-dimethyl-2(S)-aminobicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

: 148927-84-8
1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 148927-57-5
1-(((7,7-dimethyl-2-oximinobicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

: 148927-84-8
1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / H₂ / W-2 Raney Ni / 2-methoxy-ethanol / 24 h / 2844.3 Torr

2: 90 percent / BOP, diisopropylethylamine / dimethylformamide / 18 h

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; W-2 Raney Ni; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

: 60280-45-7
N-Boc-L-methionine sulfone

: 148927-84-8
1-(((7,7-dimethyl-2(S)-(2(S)-(((-tert-butyloxycarbonyl)methyl)amino)-4-(methylsulfonyl)butyramido)bicyclo<2.2.1>heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: 90 percent / BOP, diisopropylethylamine / dimethylformamide / 18 h

With sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;