N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

Base Information

Chemical Name:N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester
CAS No.:333362-90-6
Molecular Formula:C₄₈H₅₇N₆O₁₈P
Molecular Weight:1036.98
Hs Code.:

N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

Synonyms:N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

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Chemical Property of N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

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Technology Process of N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

There total 8 articles about N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-{[3-acetoxy-5-(4-allyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-allyloxy-phosphanyloxy}-1-(1-allyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid 4-phenylacetoxy-benzyl ester

: 333362-90-6
N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

Guidance literature:: With tert.-butylhydroperoxide; at 0 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(00)02121-3

Reference yield:

: (S)-2-[(S)-1-((S)-1-Allyloxycarbonyl-ethylcarbamoyl)-2-(allyloxy-diisopropylamino-phosphanyloxy)-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid 4-phenylacetoxy-benzyl ester

: 333362-90-6
N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: terazole / acetonitrile; CH₂Cl₂ / 24 h / 20 °C

2: t-BuOOH / acetonitrile; CH₂Cl₂ / 0.17 h / 0 °C

With tert.-butylhydroperoxide; terazole; In dichloromethane; acetonitrile;
DOI:10.1002/1521-3765(20020415)8:8<1879::AID-CHEM1879>3.0.CO;2-5

Reference yield:

: 192999-61-4
PhAcOZ-Pro-OH

: 333362-90-6
N-phenylacetoxybenzyloxycarbonyl-L-prolyl-L-seryl-O-(3'-O-acetyl-6-N-allyloxycarbonyl-2'-deoxycytidyl-allyl-phosphato)-L-alanine allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / HATU; DIPEA / dimethylformamide / 1 h / 0 °C

2: (iPr)2NH; tetrazole / CH₂Cl₂ / 1 h / 0 °C

3: terazole / acetonitrile; CH₂Cl₂ / 24 h / 20 °C

4: t-BuOOH / acetonitrile; CH₂Cl₂ / 0.17 h / 0 °C

With 1H-tetrazole; tert.-butylhydroperoxide; terazole; diisopropylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/1521-3765(20020415)8:8<1879::AID-CHEM1879>3.0.CO;2-5