5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

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Chemical Name:5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole
CAS No.:1417450-09-9
Molecular Formula:C₂₀H₂₁N₃O₂
Molecular Weight:335.406
Hs Code.:

Synonyms:5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

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Chemical Property of 5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

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Technology Process of 5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

There total 2 articles about 5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2398-37-0
3-methoxyphenyl bromide

: 1417450-08-8
3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

: 1417450-09-9
5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

Guidance literature:: With palladium diacetate; sodium t-butanolate; catacxium A; In toluene; at 100 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo3021677

Reference yield:

: 1417450-01-1
5-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

: 1417450-09-9
5-(3-methoxyphenyl)-3-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 70 °C

2: catacxium A; palladium diacetate; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With palladium diacetate; toluene-4-sulfonic acid; sodium t-butanolate; catacxium A; In tetrahydrofuran; toluene;
DOI:10.1021/jo3021677