acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester

Base Information

• Chemical Name: acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester
• CAS No.: 952313-02-9
• Molecular Formula: C₁₈H₂₂N₂O₆
• Molecular Weight: 362.382
• Mol file: 952313-02-9.mol

Synonyms:acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester

Chemical Property of acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester

There total 3 articles about acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-α-L-aspartyl-L-phenylalanine dimethyl ester hydrochloride + acryloyl chloride (814-68-6,25189-84-8) → acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester (952313-02-9)

Guidance literature:

N-α-L-aspartyl-L-phenylalanine dimethyl ester hydrochloride; With triethylamine; In chloroform; for 0.133333h;

acryloyl chloride; In chloroform; at 20 ℃; for 24h;

DOI:10.1039/c5cc06279a

Reference yield:

Asp-Phe-OH (3918-98-7,13433-09-5,108147-48-4,108147-49-5,130818-77-8) → acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester (952313-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / 20 °C

2: dimethylformamide / -10 - 20 °C

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1080/00397910701481146

Reference yield:

acryloyl chloride (814-68-6,25189-84-8) + methyl 3-(1-(methoxycarbonyl)-2-phenylethylcarbamoyl)-3-aminopropanoate (85412-56-2) → acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester (952313-02-9)

Guidance literature:

In N,N-dimethyl-formamide; at -10 - 20 ℃;

DOI:10.1080/00397910701481146

upstream raw materials:

acryloyl chloride

methyl 3-(1-(methoxycarbonyl)-2-phenylethylcarbamoyl)-3-aminopropanoate

Asp-Phe-OH

Refernces

• 1、 Bruechner, Peter,Koch, David,Voigtmann, Ulrike,Blechert, Siegfried. "Cross-metathesis of C-glycosides and peptides". . p. 2757 - 2769. Retrieved 2008/02/12.