Oxymetazoline hydrochloride

Base Information

• Chemical Name: Oxymetazoline hydrochloride
• CAS No.: 2315-02-8
• Molecular Formula: C16H24 N2 O . Cl H
• Molecular Weight: 296.84
• Hs Code.: 2933290000
• European Community (EC) Number: 219-015-0
• NSC Number: 757254
• UNII: K89MJ0S5VY
• DSSTox Substance ID: DTXSID80177729
• Wikidata: Q27107602
• NCI Thesaurus Code: C29313
• RXCUI: 106101
• Pharos Ligand ID: 6U25T38G9QSZ
• ChEMBL ID: CHEMBL1200791
• Mol file: 2315-02-8.mol

Synonyms:Hydrochloride, Oxymetazoline;Oxymetazoline;Oxymetazoline Hydrochloride

Chemical Property of Oxymetazoline hydrochloride

Chemical Property:

• Appearance/Colour: Off-White to Pale Yellow Solid
• Vapor Pressure: 4.59E-08mmHg at 25°C
• Melting Point: approximate 300℃ (dec.)
• Boiling Point: 431.9°Cat760mmHg
• Flash Point: 215°C
• PSA: 44.62000
• Density: 1.08g/cm³
• LogP: 3.41710
• Storage Temp.: Store at RT
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 296.1655411
• Heavy Atom Count: 20
• Complexity: 345

Purity/Quality:

97% ^*data from raw suppliers

Oxymetazoline Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 28
• Safety Statements: 22-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl
• Recent ClinicalTrials: Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea
• Recent EU Clinical Trials: A Randomized, Open-Label, Single-Dose, Parallel Group Study to Evaluate the Utility of Magnetic Resonance Imaging (MRI) in Demonstrating the Nasal Decongestant Efficacy of an Active Control (Vicks? Sinex? Micromist?) Relative to a Sham Control at 8 and 12 Hours Post-Dosing
• Uses: muscle relaxant (smooth), cerebral vasodilator Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin. Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.
• Therapeutic Function: Nasal decongestant

Technology Process of Oxymetazoline hydrochloride

There total 1 articles about Oxymetazoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Oxymetazoline hydrochloride (2315-02-8)

Guidance literature:

Reference yield:

Oxymetazoline hydrochloride (2315-02-8) → oxymetazoline (1491-59-4)

Guidance literature:

With ammonium hydroxide; at 25 - 30 ℃;

Downstream raw materials:

oxymetazoline

Refernces