22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one

Base Information

• Chemical Name: 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one
• CAS No.: 133910-21-1
• Molecular Formula: C₂₅H₄₀O₂Si
• Molecular Weight: 400.677

Synonyms:22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one

Chemical Property of 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one

Chemical Property:

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Technology Process of 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one

There total 5 articles about 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8β-ol (133910-17-5) → 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one (133910-21-1)

Guidance literature:

With dipyridinium dichromate; pyridinium trifluroacetate; In dichloromethane; for 10h; Ambient temperature;

DOI:10.1021/jm00112a021

Reference yield:

3'-iodoacetophenone (14452-30-3) → 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one (133910-21-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 1 h / 0 °C

2: CH₂Cl₂ / 12 h / 20 °C

4: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

With dipyridinium dichromate; pyridinium trifluroacetate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jm00112a021

Reference yield:

2-(3-iodophenyl)propan-2-ol (102879-20-9) → 22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8-one (133910-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 12 h / 20 °C

3: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

With dipyridinium dichromate; pyridinium trifluroacetate; In dichloromethane;

DOI:10.1021/jm00112a021

upstream raw materials:

22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norcholan-8β-ol

3'-iodoacetophenone

2-(3-iodophenyl)propan-2-ol

3-<1'-methyl-1'-(trimethylsilyloxy)ethyl>iodobenzene

Downstream raw materials:

22-<3-<1'-methyl-1'-<(trimethylsilyl)oxy>ethyl>phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate

22-(3-(Dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D₃

1α,3β-bis<(tert-butyldimethylsilyl)oxy>-22-<3-<1'-methyl-1'<(trimethylsilyl)oxy>ethyl>phenyl>-24-nor-9,10-secochola-5(10),8-dien-6-yne

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