(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

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Chemical Name:(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester
CAS No.:174497-13-3
Molecular Formula:C₂₈H₃₉N₅O₆
Molecular Weight:541.648
Hs Code.:

Synonyms:(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

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Chemical Property of (S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

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Technology Process of (S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

There total 5 articles about (S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1664-40-0
N-(2-aminoethyl)benzeneamine

: 174497-13-3
(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 16 h

2: 79 percent / 1,2-dichloro-ethane / 21 h / Heating

3: 100 percent / 1,2-dichloro-ethane / 45 h / Heating

4: aq. CF₃CO₂H / CH₂Cl₂ / 0.75 h

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ja9536072

Reference yield:

: 174497-12-2
(S)-2-(3-(2-tert-Butoxycarbonylamino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

: 174497-13-3
(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.75h;
DOI:10.1021/ja9536072

Reference yield:

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 174497-13-3
(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1,2-dichloro-ethane / 45 h / Heating

2: aq. CF₃CO₂H / CH₂Cl₂ / 0.75 h

With trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ja9536072