1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

Base Information

Chemical Name:1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one
CAS No.:1219623-87-6
Molecular Formula:C₃₀H₃₀F₃N₃O₂
Molecular Weight:521.582
Hs Code.:

Synonyms:1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

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Chemical Property of 1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

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Technology Process of 1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

There total 5 articles about 1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219623-42-3
2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid

: 55513-16-1
N-[3-(trifluoromethyl)benzyl]piperazine

: 1219623-87-6
1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₇H₁₅NO₂

: 1219623-87-6
1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; ammonia / Heating

2: potassium tert-butylate

3: water; lithium hydroxide / ethanol

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With methanol; dmap; potassium tert-butylate; ammonia; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100

Reference yield:

: 3469-00-9
methyl 2,2-diphenylacetate

: 1219623-87-6
1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane

2: methanol; ammonia / Heating

3: potassium tert-butylate

4: water; lithium hydroxide / ethanol

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With methanol; dmap; potassium tert-butylate; ammonia; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; lithium hexamethyldisilazane; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100