((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

Base Information

Chemical Name:((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester
CAS No.:1391074-15-9
Molecular Formula:C₂₅H₂₉ClN₂O₄
Molecular Weight:456.969
Hs Code.:

Synonyms:((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

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Chemical Property of ((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

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Technology Process of ((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

There total 6 articles about ((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-chlorobenzylamino)acetic acid methyl ester

: 1391077-93-2
1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid

: 1391074-15-9
((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

Guidance literature:: 1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

(4-chlorobenzylamino)acetic acid methyl ester; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1391077-90-9
1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carboxylic acid ethyl ester

: 1391074-15-9
((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / 6 h / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C

With oxalyl dichloride; water; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1391077-69-2
2-[benzyl-(2-chloroethyl)amino]propionic acid ethyl ester

: 1391074-15-9
((4-chloro-benzyl)-{1-[2-(3,5-dimethyl-phenyl)-acetyl]-2-methyl-azetidine-2-carbonyl}-amino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 - -70 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

2.1: ethanol / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / 15 h / 20 °C

5.1: sodium hydroxide / water / 15 h / 20 °C

6.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.2: 3 h / 0 °C / Inert atmosphere

With hydrogenchloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium hexamethylsilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm5012885