(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester
CAS No.:194283-79-9
Molecular Formula:C₂₁H₃₄O₆Si
Molecular Weight:410.583
Hs Code.:

Synonyms:(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Suppliers and Price of (E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

There total 8 articles about (E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 194283-78-8
Benzoic acid (2S,3S)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3-((E)-2-methoxycarbonyl-vinyloxy)-butyl ester

: 194283-79-9
(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

: [(4S,5S)-5-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-[1,3]dioxan-2-yl]-acetic acid methyl ester

Guidance literature:: With triethylamine; In methanol; water; at 0 ℃; for 42h;
DOI:10.1021/jo9702812

Reference yield:

: 84379-53-3
2-O-benzyl-3,4-O-isopropylidene-L-threitol

: 194283-79-9
(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 86 percent / PTSA / methanol; H₂O / Ambient temperature

3: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

4: 91 percent / N-methyl morpholine / CH₂Cl₂ / 10 h / Ambient temperature

5: 52 percent / Et₃N / methanol; H₂O / 42 h / 0 °C

With 4-methyl-morpholine; pyridine; 1H-imidazole; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo9702812

Reference yield:

: 21154-16-5,35572-31-7,89015-57-6,141042-56-0
diethyl-2,3-O-benzylidene-D-tartrate

: 194283-79-9
(E)-3-[(1S,2S)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-propoxy]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / LiAlH₄ / diethyl ether; CH₂Cl₂ / 1.) room temperature, 1 h, 2.) reflux, 4 h

2: 70 percent / PTSA, MS 4A / CH₂Cl₂ / 7 h / Heating

3: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 86 percent / PTSA / methanol; H₂O / Ambient temperature

5: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

6: 91 percent / N-methyl morpholine / CH₂Cl₂ / 10 h / Ambient temperature

7: 52 percent / Et₃N / methanol; H₂O / 42 h / 0 °C

With 4-methyl-morpholine; pyridine; 1H-imidazole; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo9702812