perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

Base Information

Chemical Name:perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate
CAS No.:1415839-61-0
Molecular Formula:C₂₅H₁₂Cl₂F₅N₃O₃
Molecular Weight:568.287
Hs Code.:

Synonyms:perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

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Chemical Property of perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

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Technology Process of perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

There total 5 articles about perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 1415839-61-0
perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

Guidance literature:: With dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1448419-17-7
methyl 2,4-dichloro-6-cyanoquinoline-3-carboxylate

: 1415839-61-0
perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 80 °C

2.1: lithium hydroxide; water / 1,4-dioxane / 20 °C

2.2: pH 2

3.1: dicyclohexyl-carbodiimide / 1,4-dioxane; N,N-dimethyl-formamide

With water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 159847-81-1
methyl 2-AMINO-5-CYANOBENZOATE

: 1415839-61-0
perfluorophenyl 2-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C

1.2: 0.5 h / 20 °C

1.3: 3 h / 90 °C

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 80 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 20 °C

3.2: pH 2

4.1: dicyclohexyl-carbodiimide / 1,4-dioxane; N,N-dimethyl-formamide

With water; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;