Technology Process of tert-butyl 2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenethylcarbamate
There total 6 articles about tert-butyl 2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenethylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 20 h / Reflux
2: 0.5 h / 190 °C / Microwave irradiation; neat (no solvent)
3: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
4: sodium periodate; osmium(VIII) oxide / diethyl ether; water; tert-butyl alcohol / 40 h / 20 °C
5: tert-butyldimethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; tert-butyldimethylsilane; potassium carbonate; trifluoroacetic acid;
In
diethyl ether; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
2: Claisen rearrangement / 4: Lemieux-Johnson oxidative cleavage;
DOI:10.1016/j.tet.2012.04.024
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
2: potassium hydroxide / ethanol / 2 h
3: potassium carbonate / acetone / 20 h / Reflux
4: 0.5 h / 190 °C / Microwave irradiation; neat (no solvent)
5: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
6: sodium periodate; osmium(VIII) oxide / diethyl ether; water; tert-butyl alcohol / 40 h / 20 °C
7: tert-butyldimethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; tert-butyldimethylsilane; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide;
In
diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
1: Baeyer-Villiger oxidation / 4: Claisen rearrangement / 6: Lemieux-Johnson oxidative cleavage;
DOI:10.1016/j.tet.2012.04.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 0.5 h / 190 °C / Microwave irradiation; neat (no solvent)
2: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
3: sodium periodate; osmium(VIII) oxide / diethyl ether; water; tert-butyl alcohol / 40 h / 20 °C
4: tert-butyldimethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; tert-butyldimethylsilane; trifluoroacetic acid;
In
diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
1: Claisen rearrangement / 3: Lemieux-Johnson oxidative cleavage;
DOI:10.1016/j.tet.2012.04.024
