4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

Base Information

Chemical Name:4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol
CAS No.:851778-19-3
Molecular Formula:C₂₄H₃₆O₃Si
Molecular Weight:400.634
Hs Code.:

Synonyms:4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

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Chemical Property of 4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

Chemical Property:

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Technology Process of 4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

There total 5 articles about 4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 851778-18-2
5-(tert-butyldimethylsilanyloxy)-2-methyl-1-phenyl-1-[4-(tetrahydropyran-2-yloxy)phenyl]-pentan-2-ol

: 851778-19-3
4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

Guidance literature:: With magnesium bromide; In diethyl ether; at 20 ℃; for 24h;
DOI:10.1021/jo0480951

Reference yield:

: 503025-52-3
tert-butyldimethyl-[3-(3-phenyloxiranyl)propoxy]silane

: 851778-19-3
4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 79.7 percent / copper(I) iodide / tetrahydrofuran / -40 - 20 °C

2: 82 percent / Na₂CO₃; Dess-Martin periodinane / CH₂Cl₂ / 20 °C

3: 93.5 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C

4: 84 percent / MgBr₂ / diethyl ether / 24 h / 20 °C

With copper(l) iodide; sodium carbonate; Dess-Martin periodane; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo0480951

Reference yield:

: 851778-17-1
5-(tert-butyldimethylsilanyloxy)-1-phenyl-1-[4-(tetrahydropyran-2-yloxy)phenyl]-pentan-2-one

: 851778-19-3
4-[5-(tert-butyldimethylsilanyloxy)-2-hydroxy-2-methyl-1-phenylpentyl]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 93.5 percent / tetrahydrofuran; diethyl ether / -78 - 20 °C

2: 84 percent / MgBr₂ / diethyl ether / 24 h / 20 °C

With magnesium bromide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo0480951