(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

Base Information

Chemical Name:(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide
CAS No.:118943-44-5
Molecular Formula:C₃₆H₃₉F₃N₂O₄
Molecular Weight:620.712
Hs Code.:

Synonyms:(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

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Chemical Property of (R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

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Technology Process of (R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

There total 8 articles about (R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 118943-39-8
(R)-6-amino-N-<4-(trifluoromethyl)phenyl>heptanamide

: 119065-65-5
(R)-1,2-bis(benzyloxy)-4-oxiranylbenzene

: 118943-44-5
(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

Guidance literature:: In dimethyl sulfoxide; at 10 ℃; for 23h;
DOI:10.1002/hlca.19880710204

Reference yield: 11.6%

: (R)-6-<<3,4-bis(benzyloxy)phenacyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide hydrochloride

: 118943-44-5
(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

Guidance literature:: With hydrogen; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In ethyl acetate; at 27 ℃; for 120h; under 37503 Torr;
DOI:10.1002/hlca.19880710204

Reference yield:

: 27628-06-4
1-(3,4-bis(benzyloxy)phenyl)ethan-1-one

: 118943-44-5
(R)-6-<(R)-<2-<3,4-bis(benzyloxy)phenyl>-2-hydroxyethyl>amino>-N-<4-(trifluoromethyl)phenyl>heptanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 77.9 percent / tetrahydrofuran / 0.5 h / Ambient temperature

2: 65.1 percent / tetrahydrofuran / 0.08 h / 50 °C

3: 11.6 percent / H₂, Et₃N / 2 / ethyl acetate / 120 h / 27 °C / 37503 Torr

With hydrogen; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; ethyl acetate;
DOI:10.1002/hlca.19880710204