Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

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Chemical Name:Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester
CAS No.:126568-48-7
Molecular Formula:C₃₅H₄₅N₃O₅
Molecular Weight:587.759
Hs Code.:

Synonyms:Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

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Chemical Property of Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

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Technology Process of Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

There total 17 articles about Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 126568-47-6
Benzoic acid 3-[(4-amino-butyl)-benzyl-amino]-propyl ester

: 103365-47-5
(S)-3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid

: 126568-48-7
Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; In dichloromethane; triethylamine; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(01)80739-5

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 126568-48-7
Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / Heating

2: DMAP / CH₂Cl₂ / 2 h / Ambient temperature

3: dimethylsulfoxide / 1 h / 90 °C

4: 2N NaOH / ethanol / 3 h / 90 °C

5: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium hydroxide; 2-chloro-1-methyl-pyridinium iodide; In ethanol; dichloromethane; dimethyl sulfoxide; triethylamine; toluene;
DOI:10.1016/S0040-4039(01)80739-5

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 126568-48-7
Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / Heating

2: DMAP / CH₂Cl₂ / 2 h / Ambient temperature

3: dimethylsulfoxide / 1 h / 90 °C

4: 2N NaOH / ethanol / 3 h / 90 °C

5: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium hydroxide; 2-chloro-1-methyl-pyridinium iodide; In ethanol; dichloromethane; dimethyl sulfoxide; triethylamine; toluene;
DOI:10.1016/S0040-4039(01)80739-5