N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

Base Information

Chemical Name:N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester
CAS No.:155567-91-2
Molecular Formula:C₁₆H₂₇NO₆
Molecular Weight:329.393
Hs Code.:

N<sup>α</sup>-(tert-butyloxycarbonyl)-C<sup>α</sup>-methyl-D,L-aspartic acid β-cyclohexyl ester

Synonyms:N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

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Chemical Property of N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

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Technology Process of N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

There total 5 articles about N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 155567-95-6
N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid α-benzyl β-cyclohexyl diester

: 155567-91-2
N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 4h; under 2327.2 Torr;
DOI:10.1021/ja00087a007

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 155567-91-2
N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / 2-methyl-propan-2-ol / 2 h / 80 °C

2: 47 percent / 25percent aq. NaOH / tetrahydrofuran; dioxane / 2.5 h

3: 93 percent / DMAP, DCC / CH₂Cl₂ / 1.5 h

4: 84 percent / H₂, AcOH / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr

With dmap; sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00087a007

Reference yield:

: 155567-92-3
C^α-methyl-D,L-aspartic acid α-benzyl β-methyl diester

: 155567-91-2
N^α-(tert-butyloxycarbonyl)-C^α-methyl-D,L-aspartic acid β-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / 2-methyl-propan-2-ol / 2 h / 80 °C

2: 47 percent / 25percent aq. NaOH / tetrahydrofuran; dioxane / 2.5 h

3: 93 percent / DMAP, DCC / CH₂Cl₂ / 1.5 h

4: 84 percent / H₂, AcOH / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr

With dmap; sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00087a007