Bitolterol mesylate

Base Information

• Chemical Name: Bitolterol mesylate
• CAS No.: 30392-41-7
• Molecular Formula: C29H31NO5•CH4O3S
• Molecular Weight: 557.665
• European Community (EC) Number: 250-177-5
• UNII: 4E53T3611U
• DSSTox Substance ID: DTXSID80952735
• Wikidata: Q27105949
• NCI Thesaurus Code: C65268
• ChEMBL ID: CHEMBL1200405
• Mol file: 30392-41-7.mol

Synonyms:bitolterol;bitolterol mesylate;bitolterol methanesulfonate;S-1540;Tornalate;Win 32784

Chemical Property of Bitolterol mesylate

Chemical Property:

• Vapor Pressure: 2.77E-17mmHg at 25°C
• Melting Point: 170-172°
• Boiling Point: 640.5°Cat760mmHg
• Flash Point: 341.2°C
• PSA: 147.61000
• Density: g/cm³
• LogP: 6.13900
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 557.20833825
• Heavy Atom Count: 39
• Complexity: 751

Purity/Quality:

95-99% ^*data from raw suppliers

BitolterolMesylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)OC2=C(C=C(C=C2)C(CNC(C)(C)C)O)OC(=O)C3=CC=C(C=C3)C.CS(=O)(=O)O
• Description: Bitolterol is a prodrug that releases colterol on activation by esterases in the lung. Colterol is a direct-acting agonist, and the N-t-butyl group makes it β2-selective with a binding potency equivalent to that of isoetharine and terbutaline. The ester form is lipophilic, which helps to keep it local in the lung and resistant to COMT, which tends to increase its duration of action. Onset begins 2 to 4 minutes after administration, and the effect can last as long as 8 hours. It has a adverse effect profile similar to that of other β2-selective agonists, with less drowsiness and restlessness compared to other direct-acting agonists.
• Uses: β2-adrenergic receptor agonist

Technology Process of Bitolterol mesylate

There total 1 articles about Bitolterol mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ bitolterol mesilate (30392-41-7)

Guidance literature:

Entspr. Saeure, entspr.Amin;