5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt

Base Information

• Chemical Name: 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt
• CAS No.: 324011-36-1
• Molecular Formula: C₁₆H₁₃N₃O₂S₂
• Molecular Weight: 343.43
• Mol file: 324011-36-1.mol

Synonyms:5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt

Chemical Property of 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt

There total 3 articles about 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

α-[(3-amino-3,4-dihydro-5,6-dimethyl-4-oxo-thieno[2,3-d]pyrimidin-2-yl)thio]-phenylacetic acid (324011-34-9) → 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt (324011-36-1)

Guidance literature:

With 2`,3`-dideoxycytidine; In ethanol; at 20 ℃; for 2h;

DOI:10.1002/jhet.5570370523

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt (324011-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / Et₃N / benzene / 48 h / 20 °C

2: 65 percent / DDC / ethanol / 2 h / 20 °C

With triethylamine; 2`,3`-dideoxycytidine; In ethanol; benzene;

DOI:10.1002/jhet.5570370523

Reference yield:

3-Amino-2,3-dihydro-5,6-dimethyl-2-thioxo-thieno<2,3-d>pyrimidin-4(1H)-one (170244-01-6) → 5-amino-2,3-dimethyl-8-hydroxy-4-oxo-7-phenyl-4H-thiazolo[3,2-a]thieno[3,2-e]pyrimidinium inner salt (324011-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / Et₃N / benzene / 48 h / 20 °C

2: 65 percent / DDC / ethanol / 2 h / 20 °C

With triethylamine; 2`,3`-dideoxycytidine; In ethanol; benzene;

DOI:10.1002/jhet.5570370523

upstream raw materials:

α-[(3-amino-3,4-dihydro-5,6-dimethyl-4-oxo-thieno[2,3-d]pyrimidin-2-yl)thio]-phenylacetic acid

2-bromophenylacetic acid

3-Amino-2,3-dihydro-5,6-dimethyl-2-thioxo-thieno<2,3-d>pyrimidin-4(1H)-one