4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

Base Information

Chemical Name:4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .
CAS No.:1380090-24-3
Molecular Formula:C₁₆H₁₄ClN₃O₃
Molecular Weight:331.758
Hs Code.:

Synonyms:4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

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Chemical Property of 4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

Chemical Property:

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Technology Process of 4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

There total 7 articles about 4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone . which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1380090-23-2
(4-(3-(4-chlorobenzoyl)-1-methyl-1H-pyrazol-4-yl)-3-methylisoxazol-5-yl)methyl acetate

: 1380090-24-3
4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 55 ℃; for 2h;

Reference yield:

: 84547-86-4
4-bromo-1-methyl-1H-pyrazole-3-carboxylic acid

: 1380090-24-3
4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 90 °C

4: sodium hydroxide / water; tetrahydrofuran / 2 h / 55 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1380090-20-9
4-bromo-N-methoxy-N,1-dimethyl-1H-pyrazole-3-carboxamide

: 1380090-24-3
4-chlorophenyl-(4-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)-1-methyl-1H-pyrazol-3-yl)methanone .

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 90 °C

3: sodium hydroxide / water; tetrahydrofuran / 2 h / 55 °C

With potassium carbonate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;