4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

Base Information

Chemical Name:4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol
CAS No.:459873-38-2
Molecular Formula:C₂₅H₃₂ClN₇O
Molecular Weight:482.028
Hs Code.:

Synonyms:4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

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Chemical Property of 4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

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Technology Process of 4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

There total 4 articles about 4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459872-36-7
4-{4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester

: 459873-38-2
4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;
DOI:10.1021/jm020291h

Reference yield:

: 2019-34-3
3-(4-chlorophenyl)propanoic acid

: 459873-38-2
4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 1.92 h / 20 °C

1.2: CH₂Cl₂; H₂O / 0 - 20 °C

1.3: LiAlH₄ / tetrahydrofuran / 6 h / 20 - 60 °C

2.1: 97 percent / N,N-diisopropylethylamine / tetrahydrofuran / 0 - 20 °C

3.1: Heating

4.1: HCl / dioxane / 18 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm020291h

Reference yield:

: 90944-90-4
3-(4-chlorophenyl)-1-N-methylaminopropane

: 459873-38-2
4-[2-(4-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / N,N-diisopropylethylamine / tetrahydrofuran / 0 - 20 °C

2: Heating

3: HCl / dioxane / 18 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm020291h