(S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Base Information

• Chemical Name: (S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester
• CAS No.: 1304143-54-1
• Molecular Formula: C₃₁H₄₃ClN₄O₅
• Molecular Weight: 587.159

Synonyms:(S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Chemical Property of (S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

There total 1 articles about (S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Boc-Glu(OBzl)-OH (13574-13-5) + 4-(4-(3-chlorophenyl)-piperazin-1-yl)-butan-1-amine → (S)-N2-(tert-butoxycarbonyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-54-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1007/s10989-011-9246-z

Reference yield: 100.0%

(S)-N2-(tert-butoxycarbonyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-54-1) + trifluoroacetic acid (76-05-1) → (x)C2HF3O2*C26H35ClN4O3

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1007/s10989-011-9246-z

Reference yield:

(S)-N2-(tert-butoxycarbonyl)-N1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester (1304143-54-1) → (S)-N-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}-1-(cyclohexanoyl)pyrrolidin-5-on-2-carboxamide (742115-59-9)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 1 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 8 h / 20 °C

3: hydrogen bromide; acetic acid / 3 h / 40 °C

4: thionyl chloride / chloroform / 0 °C / Reflux

With thionyl chloride; hydrogen bromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; In dichloromethane; chloroform;

DOI:10.1007/s10989-011-9246-z

upstream raw materials:

Boc-Glu(OBzl)-OH

Downstream raw materials:

(S)-N-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}-1-(cyclohexanoyl)pyrrolidin-5-on-2-carboxamide

(S)-N₂-(cyclohexanoyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1304143-54-1 (S)-N₂-(tert-butoxycarbonyl)-N₁-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}glutamylamide 5-benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send