4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1443752-70-2
• Molecular Formula: C₁₄H₁₂Cl₂N₄
• Molecular Weight: 307.182

Synonyms:4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

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Technology Process of 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

There total 4 articles about 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-methylphenyl)ethanol (1443752-68-8) → 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1443752-70-2)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; for 5h; Reflux;

DOI:10.1021/jm400233w

Reference yield:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1443752-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0 °C

3: trichlorophosphate; N,N-dimethyl-formamide / 5 h / Reflux

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jm400233w

Reference yield:

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-methylphenyl)ethanone (1443752-66-6) → 4-chloro-1-[2-chloro-2-(4-methylphenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1443752-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 °C

2: trichlorophosphate; N,N-dimethyl-formamide / 5 h / Reflux

With sodium tetrahydroborate; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jm400233w

upstream raw materials:

4-hydroxypyrazolo(3,4-d)pyrimidine

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-methylphenyl)ethanone

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-methylphenyl)ethanol

Downstream raw materials:

1-[2-chloro-2-(4-methylphenyl)ethyl]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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