(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Base Information

Chemical Name:(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol
CAS No.:916433-72-2
Molecular Formula:C₂₀H₂₈O₅
Molecular Weight:348.439
Hs Code.:

Synonyms:(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Suppliers and Price of (3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

There total 5 articles about (3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 916433-78-8
[3-but-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

: 916433-72-2
(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;
DOI:10.1021/ja0662671

Reference yield:

: 916433-76-6
3-(tert-butyldiphenylsilyloxy)hepta-2,6-dien-1-ol

: 916433-72-2
(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / (i-PrO)4Ti; 4 Angstroem molecular sieves; tert-butyl hydroperoxide / L-(+)-diethyl tartrate / CH₂Cl₂; decane / 48 h / -30 °C

2.1: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.92 h / -78 °C

3.1: n-BuLi / petroleum ether; tetrahydrofuran / 0.5 h / -78 °C

3.2: petroleum ether; tetrahydrofuran / 1.75 h / -78 - 20 °C

3.3: 25 percent / petroleum ether; tetrahydrofuran / 0.33 h / -78 °C

4.1: 87 percent / TBAF / tetrahydrofuran / 1 h

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; diethyl (2R,3R)-tartrate; In tetrahydrofuran; decane; dichloromethane; Petroleum ether; 1.1: Sharpless epoxidation / 2.1: Swern oxidation;
DOI:10.1021/ja0662671

Reference yield:

: 916433-75-5
ethyl 3-(tert-butyldiphenylsilyloxy)hepta-2,6-dienoate

: 916433-72-2
(3-but-3-enyl-3-hydroxymethyl-oxiranyl)-[3,6-dimethoxy-2-(2-methyl-allyl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / DIBAL-H / hexane; toluene / 1.5 h / -78 °C

2.1: 92 percent / (i-PrO)4Ti; 4 Angstroem molecular sieves; tert-butyl hydroperoxide / L-(+)-diethyl tartrate / CH₂Cl₂; decane / 48 h / -30 °C

3.1: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.92 h / -78 °C

4.1: n-BuLi / petroleum ether; tetrahydrofuran / 0.5 h / -78 °C

4.2: petroleum ether; tetrahydrofuran / 1.75 h / -78 - 20 °C

4.3: 25 percent / petroleum ether; tetrahydrofuran / 0.33 h / -78 °C

5.1: 87 percent / TBAF / tetrahydrofuran / 1 h

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; diethyl (2R,3R)-tartrate; In tetrahydrofuran; decane; hexane; dichloromethane; toluene; Petroleum ether; 2.1: Sharpless epoxidation / 3.1: Swern oxidation;
DOI:10.1021/ja0662671