(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

Base Information

Chemical Name:(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one
CAS No.:220077-31-6
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:368.434
Hs Code.:

Synonyms:(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

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Chemical Property of (3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

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Technology Process of (3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

There total 4 articles about (3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 69838-86-4
[α-13C]benzyl bromide

: 220077-24-7
(S)-2,3,5,6-tetrahydro-5-phenyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazine-2-one

: 220077-31-6
(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 4.5h;
DOI:10.1016/S0040-4020(98)00995-8

Reference yield:

: 54522-91-7
[α-13C]-benzyl alcohol

: 220077-31-6
(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / PBr₃ / diethyl ether / 20 h / Ambient temperature

2: 94 percent / sodium bis(trimethylsily)amide / tetrahydrofuran; 1,2-dimethoxy-ethane / 4.5 h / -78 °C

With sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether;
DOI:10.1016/S0040-4020(98)00995-8

Reference yield:

: 3880-99-7
1-(13C)benzoic acid

: 220077-31-6
(3R,5S)-2,3,5,6-tetrahydro-5-phenyl-3-phenyl[13C]methyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran

2: 65 percent / PBr₃ / diethyl ether / 20 h / Ambient temperature

3: 94 percent / sodium bis(trimethylsily)amide / tetrahydrofuran; 1,2-dimethoxy-ethane / 4.5 h / -78 °C

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether;
DOI:10.1016/S0040-4020(98)00995-8