benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

Base Information

Chemical Name:benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide
CAS No.:142966-84-5
Molecular Formula:C₂₈H₂₉N₃O₇S
Molecular Weight:551.62
Hs Code.:

Synonyms:benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

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Chemical Property of benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

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Technology Process of benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

There total 4 articles about benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 160785-86-4
benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-2-cephem-4-carboxylate

: 142966-84-5
benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 0 ℃; for 0.583333h;
DOI:10.7164/antibiotics.47.1507

Reference yield:

: 27267-35-2
7-formylamino-3-acetoxymethyl-3-cephem-4-carboxylic acid

: 142966-84-5
benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOAc; phosphate buffer, wheat bran, 2.) 1M HCl / 1.) H₂O, 18 h, pH 6.5, 2.) CH₂Cl₂, H₂O, 20 deg C, 14 h, pH 2.8

2: 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 18 h

3: 44 percent / m-CPBA / ethyl acetate / 0.58 h / 0 °C

With hydrogenchloride; phosphate buffer; wheat bran; sodium acetate; 3-chloro-benzenecarboperoxoic acid; In ethyl acetate;
DOI:10.7164/antibiotics.47.1507

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 142966-84-5
benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) acetic anhydride / 1.) 40 deg C, 30 min, 2.) r.t., 2 h

2: 1.) NaOAc; phosphate buffer, wheat bran, 2.) 1M HCl / 1.) H₂O, 18 h, pH 6.5, 2.) CH₂Cl₂, H₂O, 20 deg C, 14 h, pH 2.8

3: 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 18 h

4: 44 percent / m-CPBA / ethyl acetate / 0.58 h / 0 °C

With hydrogenchloride; phosphate buffer; wheat bran; sodium acetate; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In ethyl acetate;
DOI:10.7164/antibiotics.47.1507