2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

Base Information

Chemical Name:2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol
CAS No.:1608144-24-6
Molecular Formula:C₂₃H₂₆N₄O₅
Molecular Weight:438.483
Hs Code.:

Synonyms:2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

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Chemical Property of 2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

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Technology Process of 2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

There total 7 articles about 2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: C₂₈H₃₂N₄O₆

: 1608144-24-6
2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

Guidance literature:: C₂₈H₃₂N₄O₆; With trifluoroacetic acid; In ethanol; at 20 ℃; for 0.25h;

With potassium hydroxide; In isopropyl alcohol; for 6h; Reflux;

Reference yield:

: N-(4-(N-(hydroxymethyl)carbamimidoyl)-2-iodophenyl)acetamide

: 1608144-24-6
2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 2 h / Reflux

1.2: 1 h / 110 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 30 h / Reflux; Inert atmosphere

4.1: trifluoroacetic acid / ethanol / 0.25 h / 20 °C

4.2: 6 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 33348-34-4
4-amino-3-iodobenzonitrile

: 1608144-24-6
2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / 6 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 2 h / Reflux

3.2: 1 h / 110 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 30 h / Reflux; Inert atmosphere

6.1: trifluoroacetic acid / ethanol / 0.25 h / 20 °C

6.2: 6 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;