(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

Base Information

Chemical Name:(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid
CAS No.:1073543-74-4
Molecular Formula:C₃₀H₃₃FO₄
Molecular Weight:476.588
Hs Code.:

Synonyms:(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

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Chemical Property of (3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

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Technology Process of (3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

There total 7 articles about (3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1073545-31-9
methyl (3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoate

: 1073543-74-4
(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

Guidance literature:: methyl (3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 23 ℃; for 17h;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;

Reference yield:

: 1073544-88-3
5-(chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 1073543-74-4
(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

2.1: quinoline; hydrogen / Lindlar's catalyst / ethyl acetate / 40 h / 23 °C

3.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 17 h / 23 °C

3.2: pH 1

With quinoline; sodium hydroxide; ethanol; water; hydrogen; caesium carbonate; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1073544-86-1
(6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methanol

: 1073543-74-4
(3R,4Z)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 16 h / 23 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 22 h / 23 °C

3.1: quinoline; hydrogen / Lindlar's catalyst / ethyl acetate / 40 h / 23 °C

4.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 17 h / 23 °C

4.2: pH 1

With quinoline; sodium hydroxide; thionyl chloride; ethanol; water; hydrogen; caesium carbonate; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;