tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

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Chemical Name:tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate
CAS No.:1173159-14-2
Molecular Formula:C₅₂H₈₀N₈O₁₁
Molecular Weight:993.254
Hs Code.:

tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

Synonyms:tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

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Chemical Property of tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

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Technology Process of tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

There total 7 articles about tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanamide formate

: 137076-54-1
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

: 1173159-14-2
tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

Guidance literature:: 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 ℃; for 0.25h;

(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanamide formate; With N-ethyl-N,N-diisopropylamine; for 24h;

Reference yield:

: 1007859-08-6
N-((4-(hydroxymethyl)phenyl)methyl)prop-2-enyloxycarboxamide

: 1173159-14-2
tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 23 h / 20 °C / Inert atmosphere

1.2: 5 h / 50 °C

2.1: hydrazine hydrate / methanol / 0.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

4.1: trisodium tris(3-sulfophenyl)phosphine; diethylamine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

5.2: 24 h

With hydrazine hydrate; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1173157-52-2
C₁₃H₁₅NO₄

: 1173159-14-2
tert-butyl 2-{10-[(N-{[4-({(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-ylpropanoylaminooxy}methyl)phenyl]methyl}carbamoyl)methyl]-4,7-bis{[(tert-butyl)oxycarbonyl]methyl}-1,4,7,10-tetraazacyclododecyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 23 h / 20 °C / Inert atmosphere

2.2: 5 h / 50 °C

3.1: hydrazine hydrate / methanol / 0.5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

5.1: trisodium tris(3-sulfophenyl)phosphine; diethylamine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

6.2: 24 h

With lithium aluminium tetrahydride; hydrazine hydrate; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;