5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

Base Information

Chemical Name:5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one
CAS No.:1000192-31-3
Molecular Formula:C₁₇H₁₄ClF₃N₄O
Molecular Weight:382.773
Hs Code.:

Synonyms:5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

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Chemical Property of 5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

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Technology Process of 5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

There total 4 articles about 5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-13-1
NH-pyrazole

: C₁₄H₁₁Cl₂F₃N₂O

: 1000192-31-3
5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1016/j.bmc.2015.08.038

Reference yield:

: 58551-83-0
2,4,6-trifluorobenzaldehyde

: 1000192-31-3
5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite / water; methanol

2: chlorobenzene / 4 h / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; sodium hydrogensulfite; In methanol; water; N,N-dimethyl-formamide; chlorobenzene; 1: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.bmc.2015.08.038

Reference yield:

: C₁₂H₁₃F₃N₂

: 1000192-31-3
5-chloro-1-isobutyl-3-(pyrazol-1-yl)-6-(2,4,6-trifluorophenyl)-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: chlorobenzene / 4 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; In N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1016/j.bmc.2015.08.038