(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

Base Information

Chemical Name:(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid
CAS No.:387353-72-2
Molecular Formula:C₂₅H₄₀O₅
Molecular Weight:420.59
Hs Code.:

Synonyms:(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

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Chemical Property of (2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

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Technology Process of (2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

There total 18 articles about (2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (2S,7S)-trans-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzoyl]-8-methyl-non-4-enoic acid

: 387353-72-2
(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 33 ℃; for 72h;

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 387353-72-2
(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 30 °C

1.2: pH 2

2.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere

3.2: -70 - 5 °C

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

5.2: 5.75 h / 0 - 30 °C

6.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C

7.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere

7.2: 1 h / 0 - 5 °C

With sodium tetrahydroborate; N-chloro-succinimide; lithium hydroxide monohydrate; dihydrogen peroxide; phosphorus tribromide; magnesium; ethylene dibromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 387353-72-2
(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 5.75 h / 0 - 30 °C

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C

3.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere

3.2: 1 h / 0 - 5 °C

With sodium tetrahydroborate; N-chloro-succinimide; magnesium; ethylene dibromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;